|
|
(S)-4-Amino-5-oxopentanoate + NADP+ + tRNAMet <=> Glu-tRNAGln + NADPH + H+
|
1.2.1.70
glutamyl-tRNA reductase
|
–
|
| |
BRENDA:
BR48497
KEGG:
R04109
SABIO-RK:
9145
|
|
|
|
heme + 3 reduced_flavodoxin + 3 O2 <=> Biliverdin + Fe2+ + CO + 3 flavin + 3 H2O
|
1.14.14.18
heme oxygenase (biliverdin-producing)
1.14.99.58
heme oxygenase (biliverdin-IX-beta and delta-forming)
|
–
–
|
| |
BRENDA:
BR40384
KEGG:
R00311
|
|
|
|
sirohydrochlorin + Fe2+ <=> H+ + siroheme
|
4.99.1.3
sirohydrochlorin cobaltochelatase
4.99.1.4
sirohydrochlorin ferrochelatase
|
–
–
|
| |
BRENDA:
BR48009
KEGG:
R02864
MetaCyc:
SIROHEME-FERROCHELAT-RXN
|
|
|
|
H+ + glycine + succinyl-CoA <=> CO2 + CoA + 5-aminolevulinate
|
2.3.1.37
5-aminolevulinate synthase
|
–
|
| |
BRENDA:
BR44037
KEGG:
R00830
MetaCyc:
5-AMINOLEVULINIC-ACID-SYNTHASE-RXN
|
|
|
|
Fe-coproporphyrin_III + H2O2 + H+ <=> heme + CO2 + H2O
|
1.3.98.5
hydrogen peroxide-dependent heme synthase
|
–
|
| |
BRENDA:
BR52578
KEGG:
R11522
MetaCyc:
RXN-17519
|
|
|
|
siroheme + H+ <=> 12,18-didecarboxysiroheme + CO2
|
4.1.1.111
siroheme decarboxylase
|
–
|
| |
BRENDA:
BR51140
KEGG:
R12000
MetaCyc:
RXN-15805
|
|
|
|
S-adenosyl-L-methionine + Coproporphyrinogen-III <=> protoporphyrinogen-IX + CO2 + L-methionine + 5''-deoxyadenosine
|
1.3.98.3
coproporphyrinogen dehydrogenase
|
–
|
| |
BRENDA:
BR48612
KEGG:
R06895
MetaCyc:
HEMN-RXN
|
|
|
|
Hydroxymethylbilane <=> uroporphyrinogen_III + H2O
|
4.2.1.75
uroporphyrinogen-III synthase
|
–
|
| |
BRENDA:
BR452
KEGG:
R03165
MetaCyc:
UROGENIIISYN-RXN
|
|
|
|
S-adenosyl-L-methionine + precorrin-1 <=> S-adenosyl-L-homocysteine + precorrin-2
|
2.1.1.107
uroporphyrinogen-III C-methyltransferase
|
–
|
| |
BRENDA:
BR49530
KEGG:
R07238
MetaCyc:
RXN-8675
|
|
|
|
precorrin-2 + NAD+ <=> H+ + sirohydrochlorin + NADH
|
1.3.1.76
precorrin-2 dehydrogenase
|
–
|
| |
BRENDA:
BR47985
KEGG:
R03947
MetaCyc:
DIMETHUROPORDEHYDROG-RXN
|
|
|
|
protoporphyrinogen-IX + O2 <=> protoporphyrin_IX + H2O2
|
1.3.3.4
protoporphyrinogen oxidase
|
–
|
| |
BRENDA:
BR36840
KEGG:
R03222
MetaCyc:
PROTOPORGENOXI-RXN
SABIO-RK:
12850
|
|
|
|
(S)-4-Amino-5-oxopentanoate <=> 5-aminolevulinate
|
5.4.3.8
glutamate-1-semialdehyde 2,1-aminomutase
|
–
|
| |
BRENDA:
BR32
KEGG:
R02272
MetaCyc:
GSAAMINOTRANS-RXN
|
|
|
|
protoporphyrinogen-IX + 3 1,4-benzoquinone <=> protoporphyrin_IX + 3 hydroquinone
|
1.3.5.3
protoporphyrinogen IX dehydrogenase (quinone)
|
–
|
| |
BRENDA:
BR49166
KEGG:
R09489
|
|
|
|
uroporphyrinogen_III + H+ <=> Coproporphyrinogen-III + CO2
|
4.1.1.37
uroporphyrinogen decarboxylase
|
–
|
| |
BRENDA:
BR296
KEGG:
R03197
MetaCyc:
UROGENDECARBOX-RXN
|
|
|
|
S-adenosyl-L-methionine + uroporphyrinogen_III <=> H+ + S-adenosyl-L-homocysteine + precorrin-1
|
2.1.1.107
uroporphyrinogen-III C-methyltransferase
|
–
|
| |
BRENDA:
BR43866
KEGG:
R07237
MetaCyc:
UROPORIIIMETHYLTRANSA-RXN
|
|
|
|
5-aminolevulinate <=> H+ + H2O + porphobilinogen
|
4.2.1.24
porphobilinogen synthase
|
–
|
| |
BRENDA:
BR22826
KEGG:
R00036
MetaCyc:
PORPHOBILSYNTH-RXN
|
|
|
|
Coproporphyrinogen-III + O2 + H+ <=> protoporphyrinogen-IX + CO2 + H2O
|
1.3.3.3
coproporphyrinogen oxidase
|
–
|
| |
BRENDA:
BR36839
KEGG:
R03220
MetaCyc:
RXN0-1461
|
|
|
|
porphobilinogen + H2O <=> Hydroxymethylbilane + NH3
|
2.5.1.61
hydroxymethylbilane synthase
|
–
|
| |
BRENDA:
BR44288
KEGG:
R00084
MetaCyc:
OHMETHYLBILANESYN-RXN
SABIO-RK:
669
|
|
|
|
L-Histidinol_phosphate + 2-oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl_phosphate + L-glutamate
|
2.6.1.9
histidinol-phosphate transaminase
|
–
|
| |
BRENDA:
BR47443
KEGG:
R03243
MetaCyc:
HISTAMINOTRANS-RXN
SABIO-RK:
3064
|
|
|
|
heme + H+ <=> protoporphyrin_IX + Fe2+
|
4.99.1.1
protoporphyrin ferrochelatase
4.99.1.9
coproporphyrin ferrochelatase
|
–
–
|
| |
BRENDA:
BR3454
KEGG:
R00310
MetaCyc:
PROTOHEMEFERROCHELAT-RXN
SABIO-RK:
802
|
|
|
|
NADP+ + bilirubin <=> Biliverdin + NADPH + H+
|
1.3.1.24
biliverdin reductase
|
–
|
| |
BRENDA:
BR40361
KEGG:
R02393
MetaCyc:
BILIVERDIN-REDUCTASE-RXN
SABIO-RK:
2334
|
|
